Structure-Based Design of Potent and Selective LeishmaniaN-Myristoyltransferase Inhibitors

[Image: see text] Inhibitors of LeishmaniaN-myristoyltransferase (NMT), a potential target for the treatment of leishmaniasis, obtained from a high-throughput screen, were resynthesized to validate activity. Crystal structures bound to Leishmania major NMT were obtained, and the active diastereoisom...

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Main Authors: Hutton, Jennie A., Goncalves, Victor, Brannigan, James A., Paape, Daniel, Wright, Megan H., Waugh, Thomas M., Roberts, Shirley M., Bell, Andrew S., Wilkinson, Anthony J., Smith, Deborah F., Leatherbarrow, Robin J., Tate, Edward W.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211304/
https://ncbi.nlm.nih.gov/pubmed/25238611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5011397
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