A Two-step Mechanism for the Folding of Actin by the Yeast Cytosolic Chaperonin

Tekijä Stuart, Sarah F., Leatherbarrow, Robin J., Willison, Keith R.
Julkaistu 2011

Foot-and-mouth disease virus 3C protease: Recent structural and functional insights into an antiviral target

Tekijä Curry, Stephen, Roqué-Rosell, Núria, Zunszain, Patricia A., Leatherbarrow, Robin J.
Julkaisussa Int J Biochem Cell Biol (2007)

Structural and Mutagenic Analysis of Foot-and-Mouth Disease Virus 3C Protease Reveals the Role of the β-Ribbon in Proteolysis

Tekijä Sweeney, Trevor R., Roqué-Rosell, Núria, Birtley, James R., Leatherbarrow, Robin J., Curry, Stephen
Julkaistu 2007

Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major

Tekijä Panethymitaki, Chrysoula, Bowyer, Paul W., Price, Helen P., Leatherbarrow, Robin J., Brown, Katherine A., Smith, Deborah F.
Julkaistu 2006

Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites

Tekijä Olaleye, Tayo O., Brannigan, James A., Roberts, Shirley M., Leatherbarrow, Robin J., Wilkinson, Anthony J., Tate, Edward W.
Julkaisussa Org Biomol Chem (2014)

Using a Non-Image-Based Medium-Throughput Assay for Screening Compounds Targeting N-myristoylation in Intracellular Leishmania Amastigotes

Tekijä Paape, Daniel, Bell, Andrew S., Heal, William P., Hutton, Jennie A., Leatherbarrow, Robin J., Tate, Edward W., Smith, Deborah F.
Julkaisussa PLoS Negl Trop Dis (2014)

Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase

Tekijä Goncalves, Victor, Brannigan, James A., Laporte, Alice, Bell, Andrew S., Roberts, Shirley M., Wilkinson, Anthony J., Leatherbarrow, Robin J., Tate, Edward W.
Julkaisussa Medchemcomm (2016)

Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)

Tekijä Rackham, Mark D., Brannigan, James A., Rangachari, Kaveri, Meister, Stephan, Wilkinson, Anthony J., Holder, Anthony A., Leatherbarrow, Robin J., Tate, Edward W.
Julkaistu 2014

Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase

Tekijä Yu, Zhiyong, Brannigan, James A., Rangachari, Kaveri, Heal, William P., Wilkinson, Anthony J., Holder, Anthony A., Leatherbarrow, Robin J., Tate, Edward W.
Julkaisussa Medchemcomm (2015)

Insights into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate

Tekijä Zunszain, Patricia A., Knox, Stephen R., Sweeney, Trevor R., Yang, Jingjie, Roqué-Rosell, Núria, Belsham, Graham J., Leatherbarrow, Robin J., Curry, Stephen
Julkaisussa J Mol Biol (2010)

Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivaxN-Myristoyltransferase

Tekijä Rackham, Mark D., Brannigan, James A., Moss, David K., Yu, Zhiyong, Wilkinson, Anthony J., Holder, Anthony A., Tate, Edward W., Leatherbarrow, Robin J.
Julkaistu 2012

A fluorescence-based assay for N-myristoyltransferase activity

Tekijä Goncalves, Victor, Brannigan, James A., Thinon, Emmanuelle, Olaleye, Tayo O., Serwa, Remigiusz, Lanzarone, Salvatore, Wilkinson, Anthony J., Tate, Edward W., Leatherbarrow, Robin J.
Julkaistu 2011

Design and Synthesis of Inhibitors of Plasmodium falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery

Tekijä Yu, Zhiyong, Brannigan, James A., Moss, David K., Brzozowski, A. Marek, Wilkinson, Anthony J., Holder, Anthony A., Tate, Edward W., Leatherbarrow, Robin J.
Julkaistu 2012

Discovery of Plasmodium vivax N–Myristoyltransferase Inhibitors: Screening, Synthesis, and Structural Characterization of their Binding Mode

Tekijä Goncalves, Victor, Brannigan, James A., Whalley, David, Ansell, Keith H., Saxty, Barbara, Holder, Anthony A., Wilkinson, Anthony J., Tate, Edward W., Leatherbarrow, Robin J.
Julkaistu 2012

Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors

Tekijä Brannigan, James A., Roberts, Shirley M., Bell, Andrew S., Hutton, Jennie A., Hodgkinson, Michael R., Tate, Edward W., Leatherbarrow, Robin J., Smith, Deborah F., Wilkinson, Anthony J.
Julkaistu 2014

Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum

Tekijä Bowyer, Paul W., Gunaratne, Ruwani S., Grainger, Munira, Withers-Martinez, Chrislaine, Wickramsinghe, Sasala R., Tate, Edward W., Leatherbarrow, Robin J., Brown, Katherine A., Holder, Anthony A., Smith, Deborah F.
Julkaistu 2007

Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs

Tekijä Bell, Andrew S., Mills, James E., Williams, Gareth P., Brannigan, James A., Wilkinson, Anthony J., Parkinson, Tanya, Leatherbarrow, Robin J., Tate, Edward W., Holder, Anthony A., Smith, Deborah F.
Julkaistu 2012

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase

Tekijä Rackham, Mark D., Yu, Zhiyong, Brannigan, James A., Heal, William P., Paape, Daniel, Barker, K. Victoria, Wilkinson, Anthony J., Smith, Deborah F., Leatherbarrow, Robin J., Tate, Edward W.
Julkaisussa Medchemcomm (2015)

N-Myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis

Tekijä Brannigan, James A., Smith, Barbara A., Yu, Zhiyong, Brzozowski, Andrzej M., Hodgkinson, Michael R., Maroof, Asher, Price, Helen P., Meier, Franziska, Leatherbarrow, Robin J., Tate, Edward W., Smith, Deborah F., Wilkinson, Anthony J.
Julkaistu 2010

Structure-Based Design of Potent and Selective LeishmaniaN-Myristoyltransferase Inhibitors

Tekijä Hutton, Jennie A., Goncalves, Victor, Brannigan, James A., Paape, Daniel, Wright, Megan H., Waugh, Thomas M., Roberts, Shirley M., Bell, Andrew S., Wilkinson, Anthony J., Smith, Deborah F., Leatherbarrow, Robin J., Tate, Edward W.
Julkaistu 2014