Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major

The eukaryotic enzyme NMT (myristoyl-CoA:protein N-myristoyltransferase) has been characterized in a range of species from Saccharomyces cerevisiae to Homo sapiens. NMT is essential for viability in a number of human pathogens, including the fungi Candida albicans and Cryptococcus neoformans, and th...

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Detalhes bibliográficos
Main Authors: Panethymitaki, Chrysoula, Bowyer, Paul W., Price, Helen P., Leatherbarrow, Robin J., Brown, Katherine A., Smith, Deborah F.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462705/
https://ncbi.nlm.nih.gov/pubmed/16480339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051886
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