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Design and Synthesis of Inhibitors of Plasmodium falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery
Design of inhibitors for N-myristoyltransferase (NMT), an enzyme responsible for protein trafficking in P. falciparum, the most lethal species of parasites that cause malaria, is described. Chemistry-driven optimization of compound 1 from a focused NMT inhibitor library led to the identification of...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3863768/ https://ncbi.nlm.nih.gov/pubmed/23035716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301160h |
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