Design and Synthesis of Inhibitors of Plasmodium falciparum N-Myristoyltransferase, a Promising Target for Anti-Malarial Drug Discovery

Design of inhibitors for N-myristoyltransferase (NMT), an enzyme responsible for protein trafficking in P. falciparum, the most lethal species of parasites that cause malaria, is described. Chemistry-driven optimization of compound 1 from a focused NMT inhibitor library led to the identification of...

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Hauptverfasser: Yu, Zhiyong, Brannigan, James A., Moss, David K., Brzozowski, A. Marek, Wilkinson, Anthony J., Holder, Anthony A., Tate, Edward W., Leatherbarrow, Robin J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863768/
https://ncbi.nlm.nih.gov/pubmed/23035716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301160h
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