Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase

The parasite Plasmodium vivax is the most widely distributed cause of recurring malaria. N-Myristoyltransferase (NMT), an enzyme that catalyses the covalent attachment of myristate to the N-terminal glycine of substrate proteins, has been described as a potential target for the treatment of this dis...

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Bibliografische gegevens
Gepubliceerd in:Medchemcomm
Hoofdauteurs: Goncalves, Victor, Brannigan, James A., Laporte, Alice, Bell, Andrew S., Roberts, Shirley M., Wilkinson, Anthony J., Leatherbarrow, Robin J., Tate, Edward W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Royal Society of Chemistry 2016
Onderwerpen:
Chemistry
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5463734/
https://ncbi.nlm.nih.gov/pubmed/28626547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00531d
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