Insights into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate

Picornavirus replication is critically dependent on the correct processing of a polyprotein precursor by 3C protease(s) (3C(pro)) at multiple specific sites with related but non-identical sequences. To investigate the structural basis of its cleavage specificity, we performed the first crystallograp...

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Bibliographic Details
Published in:J Mol Biol
Main Authors: Zunszain, Patricia A., Knox, Stephen R., Sweeney, Trevor R., Yang, Jingjie, Roqué-Rosell, Núria, Belsham, Graham J., Leatherbarrow, Robin J., Curry, Stephen
Format: Artigo
Language:Inglês
Published: Elsevier Inc. 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7099390/
https://ncbi.nlm.nih.gov/pubmed/19883658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.10.048
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