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Structural and Mutagenic Analysis of Foot-and-Mouth Disease Virus 3C Protease Reveals the Role of the β-Ribbon in Proteolysis

The 3C protease (3C(pro)) from foot-and-mouth disease virus (FMDV), the causative agent of a widespread and economically devastating disease of domestic livestock, is a potential target for antiviral drug design. We have determined the structure of a new crystal form of FMDV 3C(pro), a chymotrypsin-...

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Detalhes bibliográficos
Main Authors: Sweeney, Trevor R., Roqué-Rosell, Núria, Birtley, James R., Leatherbarrow, Robin J., Curry, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797255/
https://ncbi.nlm.nih.gov/pubmed/17065215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01587-06
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