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Structure of Foot-and-Mouth Disease Virus Mutant Polymerases with Reduced Sensitivity to Ribavirin

Passage of poliovirus (PV) or foot-and-mouth disease virus (FMDV) in the presence of ribavirin (R) selected for viruses with decreased sensitivity to R, which included different mutations in their polymerase (3D): G64S located in the finger subdomain in the case of PV and M296I located within loop β...

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Main Authors: Ferrer-Orta, Cristina, Sierra, Macarena, Agudo, Rubén, de la Higuera, Ignacio, Arias, Armando, Pérez-Luque, Rosa, Escarmís, Cristina, Domingo, Esteban, Verdaguer, Nuria
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876637/
https://ncbi.nlm.nih.gov/pubmed/20392853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02420-09
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