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Foot-and-Mouth Disease Virus Mutant with Decreased Sensitivity to Ribavirin: Implications for Error Catastrophe

The nucleoside analogue ribavirin (R) is mutagenic for foot-and-mouth disease virus (FMDV). Passage of FMDV in the presence of increasing concentrations of R resulted in the selection of FMDV with the amino acid substitution M296I in the viral polymerase (3D). Measurements of progeny production and...

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Bibliografske podrobnosti
Main Authors: Sierra, Macarena, Airaksinen, Antero, González-López, Claudia, Agudo, Rubén, Arias, Armando, Domingo, Esteban
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797574/
https://ncbi.nlm.nih.gov/pubmed/17151116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01606-06
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