Determinants of RNA-Dependent RNA Polymerase (In)fidelity Revealed by Kinetic Analysis of the Polymerase Encoded by a Foot-and-Mouth Disease Virus Mutant with Reduced Sensitivity to Ribavirin

A mutant poliovirus (PV) encoding a change in its polymerase (3Dpol) at a site remote from the catalytic center (G64S) confers reduced sensitivity to ribavirin and forms a restricted quasispecies, because G64S 3Dpol is a high-fidelity enzyme. A foot-and-mouth disease virus (FMDV) mutant that encodes...

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Detalhes bibliográficos
Main Authors: Arias, Armando, Arnold, Jamie J., Sierra, Macarena, Smidansky, Eric D., Domingo, Esteban, Cameron, Craig E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593321/
https://ncbi.nlm.nih.gov/pubmed/18829745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01297-08
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