Attenuation of Foot-and-Mouth Disease Virus by Engineered Viral Polymerase Fidelity

Foot-and-mouth disease virus (FMDV) RNA-dependent RNA polymerase (RdRp) (3D(pol)) catalyzes viral RNA synthesis. Its characteristic low fidelity and absence of proofreading activity allow FMDV to rapidly mutate and adapt to dynamic environments. In this study, we used the structure of FMDV 3D(pol) i...

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Detaylı Bibliyografya
Yayımlandı:J Virol
Asıl Yazarlar: Rai, Devendra K., Diaz-San Segundo, Fayna, Campagnola, Grace, Keith, Anna, Schafer, Elizabeth A., Kloc, Anna, de los Santos, Teresa, Peersen, Olve, Rieder, Elizabeth
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2017
Konular:
Genome Replication and Regulation of Viral Gene Expression
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651715/
https://ncbi.nlm.nih.gov/pubmed/28515297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00081-17
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