Attenuation of Foot-and-Mouth Disease Virus by Engineered Viral Polymerase Fidelity

Foot-and-mouth disease virus (FMDV) RNA-dependent RNA polymerase (RdRp) (3D(pol)) catalyzes viral RNA synthesis. Its characteristic low fidelity and absence of proofreading activity allow FMDV to rapidly mutate and adapt to dynamic environments. In this study, we used the structure of FMDV 3D(pol) i...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Rai, Devendra K., Diaz-San Segundo, Fayna, Campagnola, Grace, Keith, Anna, Schafer, Elizabeth A., Kloc, Anna, de los Santos, Teresa, Peersen, Olve, Rieder, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651715/
https://ncbi.nlm.nih.gov/pubmed/28515297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00081-17
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