Structure-Function Relationships Underlying the Replication Fidelity of Viral RNA-Dependent RNA Polymerases

Viral RNA-dependent RNA polymerases are considered to be low-fidelity enzymes, providing high mutation rates that allow for the rapid adaptation of RNA viruses to different host cell environments. Fidelity is tuned to provide the proper balance of virus replication rates, pathogenesis, and tissue tr...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Campagnola, Grace, McDonald, Seth, Beaucourt, Stéphanie, Vignuzzi, Marco, Peersen, Olve B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301111/
https://ncbi.nlm.nih.gov/pubmed/25320316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01574-14
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