Viral Polymerase-Helicase Complexes Regulate Replication Fidelity To Overcome Intracellular Nucleotide Depletion

To date, the majority of work on RNA virus replication fidelity has focused on the viral RNA polymerase, while the potential role of other viral replicase proteins in this process is poorly understood. Previous studies used resistance to broad-spectrum RNA mutagens, such as ribavirin, to identify po...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Stapleford, Kenneth A., Rozen-Gagnon, Kathryn, Das, Pratyush Kumar, Saul, Sirle, Poirier, Enzo Z., Blanc, Hervé, Vidalain, Pierre-Olivier, Merits, Andres, Vignuzzi, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645662/
https://ncbi.nlm.nih.gov/pubmed/26311883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01553-15
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