Viral Polymerase-Helicase Complexes Regulate Replication Fidelity To Overcome Intracellular Nucleotide Depletion

To date, the majority of work on RNA virus replication fidelity has focused on the viral RNA polymerase, while the potential role of other viral replicase proteins in this process is poorly understood. Previous studies used resistance to broad-spectrum RNA mutagens, such as ribavirin, to identify po...

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Bibliografische gegevens
Gepubliceerd in:J Virol
Hoofdauteurs: Stapleford, Kenneth A., Rozen-Gagnon, Kathryn, Das, Pratyush Kumar, Saul, Sirle, Poirier, Enzo Z., Blanc, Hervé, Vidalain, Pierre-Olivier, Merits, Andres, Vignuzzi, Marco
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2015
Onderwerpen:
Genome Replication and Regulation of Viral Gene Expression
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4645662/
https://ncbi.nlm.nih.gov/pubmed/26311883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01553-15
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