Low-Fidelity Polymerases of Alphaviruses Recombine at Higher Rates To Overproduce Defective Interfering Particles

Low-fidelity RNA-dependent RNA polymerases for many RNA virus mutators have been shown to confer attenuated phenotypes, presumably due to increased mutation rates. Additionally, for many RNA viruses, replication to high titers results in the production of defective interfering particles (DIs) that a...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Poirier, Enzo Z., Mounce, Bryan C., Rozen-Gagnon, Kathryn, Hooikaas, Peter Jan, Stapleford, Kenneth A., Moratorio, Gonzalo, Vignuzzi, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810721/
https://ncbi.nlm.nih.gov/pubmed/26676773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02921-15
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