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Alphavirus Mutator Variants Present Host-Specific Defects and Attenuation in Mammalian and Insect Models

Arboviruses cycle through both vertebrates and invertebrates, which requires them to adapt to disparate hosts while maintaining genetic integrity during genome replication. To study the genetic mechanisms and determinants of these processes, we use chikungunya virus (CHIKV), a re-emerging human path...

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Detalhes bibliográficos
Main Authors: Rozen-Gagnon, Kathryn, Stapleford, Kenneth A., Mongelli, Vanesa, Blanc, Hervé, Failloux, Anna-Bella, Saleh, Maria-Carla, Vignuzzi, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894214/
https://ncbi.nlm.nih.gov/pubmed/24453971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003877
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