Alphavirus Mutator Variants Present Host-Specific Defects and Attenuation in Mammalian and Insect Models

Arboviruses cycle through both vertebrates and invertebrates, which requires them to adapt to disparate hosts while maintaining genetic integrity during genome replication. To study the genetic mechanisms and determinants of these processes, we use chikungunya virus (CHIKV), a re-emerging human path...

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Autores principales: Rozen-Gagnon, Kathryn, Stapleford, Kenneth A., Mongelli, Vanesa, Blanc, Hervé, Failloux, Anna-Bella, Saleh, Maria-Carla, Vignuzzi, Marco
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894214/
https://ncbi.nlm.nih.gov/pubmed/24453971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003877
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