Mutations in Coronavirus Nonstructural Protein 10 Decrease Virus Replication Fidelity

Coronaviruses (CoVs) are unique in encoding a 3′→5′ exoribonuclease within nonstructural protein 14 (nsp14-ExoN) that is required for high-fidelity replication, likely via proofreading. nsp14 associates with the CoV RNA-dependent RNA polymerase (nsp12-RdRp), and nsp14-ExoN activity is enhanced by bi...

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Publicat a:J Virol
Autors principals: Smith, Everett Clinton, Case, James Brett, Blanc, Hervé, Isakov, Ofer, Shomron, Noam, Vignuzzi, Marco, Denison, Mark R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
Matèries:
Genome Replication and Regulation of Viral Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4474304/
https://ncbi.nlm.nih.gov/pubmed/25855750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00110-15
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