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Mutations in Coronavirus Nonstructural Protein 10 Decrease Virus Replication Fidelity
Coronaviruses (CoVs) are unique in encoding a 3′→5′ exoribonuclease within nonstructural protein 14 (nsp14-ExoN) that is required for high-fidelity replication, likely via proofreading. nsp14 associates with the CoV RNA-dependent RNA polymerase (nsp12-RdRp), and nsp14-ExoN activity is enhanced by bi...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Virol |
|---|---|
| Κύριοι συγγραφείς: | , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Microbiology
2015
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4474304/ https://ncbi.nlm.nih.gov/pubmed/25855750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00110-15 |
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