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High Fidelity of Murine Hepatitis Virus Replication Is Decreased in nsp14 Exoribonuclease Mutants

Replication fidelity of RNA virus genomes is constrained by the opposing necessities of generating sufficient diversity for adaptation and maintaining genetic stability, but it is unclear how the largest viral RNA genomes have evolved and are maintained under these constraints. A coronavirus (CoV) n...

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Detalhes bibliográficos
Main Authors: Eckerle, Lance D., Lu, Xiaotao, Sperry, Steven M., Choi, Leena, Denison, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169014/
https://ncbi.nlm.nih.gov/pubmed/17804504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01296-07
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