The coronavirus nsp14 exoribonuclease interface with the cofactor nsp10 is essential for efficient virus replication and enzymatic activity

ABSTRACT Coronaviruses (CoVs) encode non-structural proteins (nsp’s) 1–16, which assemble to form replication-transcription complexes that function in viral RNA synthesis. All CoVs encode a proofreading 3′−5′ exoribonuclease in non-structural protein 14 (nsp14-ExoN) that mediates proofreading and hi...

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Prif Awduron:	Samantha L. Grimes, Brook E. Heaton, Mackenzie L. Anderson, Katie Burke, Laura Stevens, Xiaotao Lu, Nicholas S. Heaton, Mark R. Denison, Jordan Anderson-Daniels
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	American Society for Microbiology 2025-02-01
Cyfres:	Journal of Virology
Pynciau:	coronavirus exoribonuclease replication nsp14 nsp10 competitive fitness
Mynediad Ar-lein:	https://journals.asm.org/doi/10.1128/jvi.01708-24
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