The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2

Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3′-to-5′ exoribonuclease (ExoN) and guanine-N7-methyltransferase (N7-MTase) domains. While the latter presumably supports mRNA...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Ogando, Natacha S., Zevenhoven-Dobbe, Jessika C., van der Meer, Yvonne, Bredenbeek, Peter J., Posthuma, Clara C., Snijder, Eric J.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2020
Sujets:
Genome Replication and Regulation of Viral Gene Expression
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654266/
https://ncbi.nlm.nih.gov/pubmed/32938769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01246-20
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