Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens

Positive-sense RNA viruses encode RNA-dependent RNA polymerases (RdRps) essential for genomic replication. With the exception of the large nidoviruses, such as coronaviruses (CoVs), RNA viruses lack proofreading and thus are dependent on RdRps to control nucleotide selectivity and fidelity. CoVs enc...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Sexton, Nicole R., Smith, Everett Clinton, Blanc, Hervé, Vignuzzi, Marco, Peersen, Olve B., Denison, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984655/
https://ncbi.nlm.nih.gov/pubmed/27279608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00080-16
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