Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens

Positive-sense RNA viruses encode RNA-dependent RNA polymerases (RdRps) essential for genomic replication. With the exception of the large nidoviruses, such as coronaviruses (CoVs), RNA viruses lack proofreading and thus are dependent on RdRps to control nucleotide selectivity and fidelity. CoVs enc...

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Vydáno v:J Virol
Hlavní autoři: Sexton, Nicole R., Smith, Everett Clinton, Blanc, Hervé, Vignuzzi, Marco, Peersen, Olve B., Denison, Mark R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Genome Replication and Regulation of Viral Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984655/
https://ncbi.nlm.nih.gov/pubmed/27279608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00080-16
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