Structure-Function Relationships Underlying the Replication Fidelity of Viral RNA-Dependent RNA Polymerases

Viral RNA-dependent RNA polymerases are considered to be low-fidelity enzymes, providing high mutation rates that allow for the rapid adaptation of RNA viruses to different host cell environments. Fidelity is tuned to provide the proper balance of virus replication rates, pathogenesis, and tissue tr...

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Detalles Bibliográficos
Publicado en:J Virol
Autores principales: Campagnola, Grace, McDonald, Seth, Beaucourt, Stéphanie, Vignuzzi, Marco, Peersen, Olve B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301111/
https://ncbi.nlm.nih.gov/pubmed/25320316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01574-14
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