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Polymerase Fidelity Contributes to Foot-and-Mouth Disease Virus Pathogenicity and Transmissibility In Vivo

The low fidelity of foot-and-mouth disease virus (FMDV) RNA-dependent RNA polymerase allows FMDV to exhibit high genetic diversity. Previously, we showed that the genetic diversity of FMDV plays an important role in virulence in suckling mice. Here, we mutated the amino acid residue Phe257, located...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Li, Chen, Shi, Jiabao, Wang, Haiwei, Rivera-Serrano, Efraín E., Yang, Decheng, Zhou, Guohui, Sun, Chao, Cameron, Craig E., Yu, Li
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7737748/
https://ncbi.nlm.nih.gov/pubmed/33028719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01569-20
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