Ribavirin-Resistant Variants of Foot-and-Mouth Disease Virus: the Effect of Restricted Quasispecies Diversity on Viral Virulence

Mutagenic nucleoside analogues can be used to isolate RNA virus high-fidelity RNA-dependent RNA polymerase (RdRp) variants, the majority of which are attenuated in vivo. However, attenuated foot-and-mouth disease virus (FMDV) high-fidelity RdRp variants have not been isolated, and the correlations b...

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Detalhes bibliográficos
Principais autores: Zeng, Jianxiong, Wang, Haiwei, Xie, Xiaochun, Li, Chen, Zhou, Guohui, Yang, Decheng, Yu, Li
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993757/
https://ncbi.nlm.nih.gov/pubmed/24453363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03594-13
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