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Single amino acid substitution of VP1 N17D or VP2 H145Y confers acid-resistant phenotype of type Asia1 foot-and-mouth disease virus

Infection by foot-and-mouth disease virus (FMDV) is triggered by the acidic pH in endosomes after virus uptake by receptor-mediated endocytosis. However, dissociation of the FMDV 146S particle in mildly acidic conditions renders inactivated foot-and-mouth disease (FMD) vaccines much less effective....

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書目詳細資料
發表在:Virol Sin
Main Authors: Wang, Haiwei, Song, Shanshan, Zeng, Jianxiong, Zhou, Guohui, Yang, Decheng, Liang, Te, Yu, Li
格式: Artigo
語言:Inglês
出版: Wuhan Institute of Virology, CAS 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8206435/
https://ncbi.nlm.nih.gov/pubmed/24752763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12250-014-3426-x
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