Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs

Inhibition of N-myristoyltransferase has been validated pre-clinically as a target for the treatment of fungal and trypanosome infections, using species-specific inhibitors. In order to identify inhibitors of protozoan NMTs, we chose to screen a diverse subset of the Pfizer corporate collection agai...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bell, Andrew S., Mills, James E., Williams, Gareth P., Brannigan, James A., Wilkinson, Anthony J., Parkinson, Tanya, Leatherbarrow, Robin J., Tate, Edward W., Holder, Anthony A., Smith, Deborah F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3335879/
https://ncbi.nlm.nih.gov/pubmed/22545171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001625
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg