Challenges for and current status of research into positive modulators of AMPA receptors

Por Ward, Simon E, Bax, Benjamin D, Harries, Mark
Publicado em 2010

Liver Immune Microenvironment and Metastasis from Colorectal Cancer-Pathogenesis and Therapeutic Perspectives

Por Zeng, Xuezhen, Ward, Simon E., Zhou, Jingying, Cheng, Alfred S. L.
Publicado no Cancers (Basel) (2021)

TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan

Por Meisenberg, Cornelia, Ward, Simon E, Schmid, Peter, El-Khamisy, Sherif F
Publicado em 2014

Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions

Por Henderson, Scott H., West, Ryan A., Ward, Simon E., Honey, Mark A.
Publicado no R Soc Open Sci (2018)

Small molecule inhibits T-cell acute lymphoblastic leukaemia oncogenic interaction through conformational modulation of LMO2

Por Milton-Harris, Leanne, Jeeves, Mark, Walker, Sarah A., Ward, Simon E., Mancini, Erika J.
Publicado no Oncotarget (2020)

Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan

Por Meisenberg, Cornelia, Gilbert, Duncan C, Chalmers, Anthony, Haley, Vikki, Gollins, Simon, Ward, Simon E., El-Khamisy, Sherif F.
Publicado no Mol Cancer Ther (2014)

Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer

Por Scott, Fiona, Fala, Angela M., Pennicott, Lewis E., Reuillon, Tristan D., Massirer, Katlin B., Elkins, Jonathan M., Ward, Simon E.
Publicado no Bioorg Med Chem Lett (2020)

Mining Public Domain Data to Develop Selective DYRK1A Inhibitors

Por Henderson, Scott H., Sorrell, Fiona, Bennett, James, Hanley, Marcus T., Robinson, Sean, Hopkins Navratilova, Iva, Elkins, Jonathan M., Ward, Simon E.
Publicado no ACS Med Chem Lett (2020)

d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity

Por Kirkwood, Nerissa K., O'Reilly, Molly, Derudas, Marco, Kenyon, Emma J., Huckvale, Rosemary, van Netten, Sietse M., Ward, Simon E., Richardson, Guy P., Kros, Corné J.
Publicado no Front Cell Neurosci (2017)

Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan

Por Meisenberg, Cornelia, Ashour, Mohamed E., El-Shafie, Lamia, Liao, Chunyan, Hodgson, Adam, Pilborough, Alice, Khurram, Syed A., Downs, Jessica A., Ward, Simon E., El-Khamisy, Sherif F.
Publicado no Nucleic Acids Res (2017)

African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase

Por West, Ryan A., O'Doherty, Oran G., Askwith, Trevor, Atack, John, Beswick, Paul, Laverick, Jamie, Paradowski, Michael, Pennicott, Lewis E., Rao, Srinivasa P.S., Williams, Gareth, Ward, Simon E.
Publicado no Eur J Med Chem (2017)

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct

Por Ocasio, Cory A., Rajasekaran, Mohan B., Walker, Sarah, Le Grand, Darren, Spencer, John, Pearl, Frances M.G., Ward, Simon E., Savic, Velibor, Pearl, Laurence H., Hochegger, Helfrid, Oliver, Antony W.
Publicado no Oncotarget (2016)

Pharmacological characterisation of MDI-222, a novel AMPA receptor positive allosteric modulator with an improved safety profile

Por Ward, Simon E, Harries, Mark H, Aldegheri, Laura, Bradford, Andrea M, Ballini, Elisa, Dawson, Lee, Lacroix, Laurent, Pardoe, Joanne, Starr, Kathryn, Weil, Annette, Waters, Kerry, Atack, John R, Woolley, Marie
Publicado no J Psychopharmacol (2020)

Pharmacological characterization of N‐[(2S)‐5‐(6‐fluoro‐3‐pyridinyl)‐2, 3‐dihydro‐1H‐inden‐2‐yl]‐2‐propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator...

Por Ward, Simon E, Beswick, Paul, Calcinaghi, Novella, Dawson, Lee A, Gartlon, Jane, Graziani, Francesca, Jones, Declan N C, Lacroix, Laurent, Selina Mok, M H, Oliosi, Beatrice, Pardoe, Joanne, Starr, Kathryn, Woolley, Marie L, Harries, Mark H
Publicado no Br J Pharmacol (2017)

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

Por Chen, Xiangrong, Ali, Yusuf I, Fisher, Charlotte EL, Arribas-Bosacoma, Raquel, Rajasekaran, Mohan B, Williams, Gareth, Walker, Sarah, Booth, Jessica R, Hudson, Jessica JR, Roe, S Mark, Pearl, Laurence H, Ward, Simon E, Pearl, Frances MG, Oliver, Antony W
Publicado no eLife (2021)

Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death

Por Kenyon, Emma J., Kirkwood, Nerissa K., Kitcher, Siân R., O’Reilly, Molly, Derudas, Marco, Cantillon, Daire M., Goodyear, Richard J., Secker, Abigail, Baxendale, Sarah, Bull, James C., Waddell, Simon J., Whitfield, Tanya T., Ward, Simon E., Kros, Corné J., Richardson, Guy P.
Publicado no JCI Insight (2017)

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2

Por Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E., Bartlett, Edward J., Brissett, Nigel C., Raoof, Ali, Watson, Mandy, Jordan, Allan M., Ogilvie, Donald J., Ward, Simon E., Atack, John R., Pearl, Laurence H., Caldecott, Keith W., Oliver, Antony W.
Publicado no Biochem J (2016)

Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity

Por Kenyon, Emma J., Kirkwood, Nerissa K., Kitcher, Siân R., Goodyear, Richard J., Derudas, Marco, Cantillon, Daire M., Baxendale, Sarah, de la Vega de León, Antonio, Mahieu, Virginia N., Osgood, Richard T., Wilson, Charlotte Donald, Bull, James C., Waddell, Simon J., Whitfield, Tanya T., Ward, Simon E., Kros, Corné J., Richardson, Guy P.
Publicado no JCI Insight (2021)