Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase

Por Cole, Ambrose R., Ofer, Sapir, Ryzhenkova, Ksenia, Baltulionis, Gediminas, Hornyak, Peter, Savva, Renos
Publicado em 2013

The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function

Por Breslin, Claire, Hornyak, Peter, Ridley, Andrew, Rulten, Stuart L., Hanzlikova, Hana, Oliver, Antony W., Caldecott, Keith W.
Publicado no Nucleic Acids Res (2015)

XRCC1 Mutation is Associated with PARP1 Hyperactivation and Cerebellar Ataxia

Por Hoch, Nicolas, Hanzlikova, Hana, Rulten, Stuart L., Tétreault, Martine, Koumulainen, Emilia, Ju, Limei, Hornyak, Peter, Zeng, Zhihong, Gittens, William, Rey, Stephanie, Staras, Kevin, Mancini, Grazia M.S., McKinnon, Peter J., Wang, Zhao-Qi, Wagner, Justin, Yoon, Grace, Caldecott, Keith W.
Publicado no Nature (2016)

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2

Por Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E., Bartlett, Edward J., Brissett, Nigel C., Raoof, Ali, Watson, Mandy, Jordan, Allan M., Ogilvie, Donald J., Ward, Simon E., Atack, John R., Pearl, Laurence H., Caldecott, Keith W., Oliver, Antony W.
Publicado no Biochem J (2016)