Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan

The topoisomerase I (TOP1) inhibitor irinotecan triggers cell death by trapping TOP1 on DNA, generating cytotoxic protein-linked DNA breaks (PDBs). Despite its wide application in a variety of solid tumors, the mechanisms of cancer cell resistance to irinotecan remains poorly understood. Here, we ge...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Meisenberg, Cornelia, Ashour, Mohamed E., El-Shafie, Lamia, Liao, Chunyan, Hodgson, Adam, Pilborough, Alice, Khurram, Syed A., Downs, Jessica A., Ward, Simon E., El-Khamisy, Sherif F.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5388393/
https://ncbi.nlm.nih.gov/pubmed/28180300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1026
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