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Methylation-directed acetylation of histone H3 regulates developmental sensitivity to histone deacetylase inhibition
Hydroxamate-based lysine deacetylase inhibitors (KDACis) are approved for clinical use against certain cancers. However, intrinsic and acquired resistance presents a major problem. Treatment of cells with hydroxamates such as trichostatin A (TSA) leads to rapid preferential acetylation of histone H3...
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| 發表在: | Nucleic Acids Res |
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| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8053100/ https://ncbi.nlm.nih.gov/pubmed/33721015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab154 |
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