Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes

Polycomb group (PcG) proteins are transcriptional repressors, which regulate proliferation and cell fate decisions during development, and their deregulated expression is a frequent event in human tumours. The Polycomb repressive complex 2 (PRC2) catalyzes trimethylation (me3) of histone H3 lysine 2...

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Hlavní autoři: Pasini, Diego, Malatesta, Martina, Jung, Hye Ryung, Walfridsson, Julian, Willer, Anton, Olsson, Linda, Skotte, Julie, Wutz, Anton, Porse, Bo, Jensen, Ole Nørregaard, Helin, Kristian
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
Témata:
Gene Regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2926606/
https://ncbi.nlm.nih.gov/pubmed/20385584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq244
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