Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes

Polycomb group (PcG) proteins are transcriptional repressors, which regulate proliferation and cell fate decisions during development, and their deregulated expression is a frequent event in human tumours. The Polycomb repressive complex 2 (PRC2) catalyzes trimethylation (me3) of histone H3 lysine 2...

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Bibliographische Detailangaben
Hauptverfasser: Pasini, Diego, Malatesta, Martina, Jung, Hye Ryung, Walfridsson, Julian, Willer, Anton, Olsson, Linda, Skotte, Julie, Wutz, Anton, Porse, Bo, Jensen, Ole Nørregaard, Helin, Kristian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
Schlagworte:
Gene Regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2926606/
https://ncbi.nlm.nih.gov/pubmed/20385584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq244
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