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Quantitative Mass Spectrometry of Histones H3.2 and H3.3 in Suz12-deficient Mouse Embryonic Stem Cells Reveals Distinct, Dynamic Post-translational Modifications at Lys-27 and Lys-36

SUZ12 is a core component of the polycomb repressive complex 2 (PRC2) and is required for the differentiation of mouse embryonic stem cells (ESCs). PRC2 is associated with transcriptional repression via methylation of H3 Lys-27. We applied quantitative mass spectrometry to investigate the effects of...

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Bibliografische gegevens
Hoofdauteurs: Jung, Hye Ryung, Pasini, Diego, Helin, Kristian, Jensen, Ole N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Biochemistry and Molecular Biology 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871418/
https://ncbi.nlm.nih.gov/pubmed/20150217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M900489-MCP200
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