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Quantitative Mass Spectrometry of Histones H3.2 and H3.3 in Suz12-deficient Mouse Embryonic Stem Cells Reveals Distinct, Dynamic Post-translational Modifications at Lys-27 and Lys-36

SUZ12 is a core component of the polycomb repressive complex 2 (PRC2) and is required for the differentiation of mouse embryonic stem cells (ESCs). PRC2 is associated with transcriptional repression via methylation of H3 Lys-27. We applied quantitative mass spectrometry to investigate the effects of...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Jung, Hye Ryung, Pasini, Diego, Helin, Kristian, Jensen, Ole N.
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Biochemistry and Molecular Biology 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871418/
https://ncbi.nlm.nih.gov/pubmed/20150217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M900489-MCP200
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