Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2

The Polycomb repressive complex 2 (PRC2) catalyzes H3K27 methylation and is required for maintaining transcriptional patterns and cellular identity, but the specification and maintenance of genomic PRC2 binding and H3K27 methylation patterns remain incompletely understood. Epigenetic mechanisms have...

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Udgivet i:Nat Struct Mol Biol
Main Authors: Højfeldt, Jonas W, Laugesen, Anne, Willumsen, Berthe M, Damhofer, Helene, Hedehus, Lin, Tvardovskiy, Andrey, Mohammad, Faizaan, Jensen, Ole N, Helin, Kristian
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5842896/
https://ncbi.nlm.nih.gov/pubmed/29483650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0036-6
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