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Non-core subunits of the PRC2 complex are collectively required for its target site specificity

The Polycomb repressive complex 2 (PRC2) catalyzes H3K27 methylation across the genome, which impacts transcriptional regulation and is critical for establishment of cell identity. Because of its essential function during development and in cancer, understanding the delineation of genome-wide H3K27...

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Publicat a:Mol Cell
Autors principals: Westergaard Højfeldt, Jonas, Hedehus, Lin, Laugesen, Anne, Tatar, Tülin, Wiehle, Laura, Helin, Kristian
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842426/
https://ncbi.nlm.nih.gov/pubmed/31521506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.031
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