Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity

To identify small molecules that shield mammalian sensory hair cells from the ototoxic side effects of aminoglycoside antibiotics, 10,240 compounds were initially screened in zebrafish larvae, selecting for those that protected lateral-line hair cells against neomycin and gentamicin. When the 64 hit...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Kenyon, Emma J., Kirkwood, Nerissa K., Kitcher, Siân R., Goodyear, Richard J., Derudas, Marco, Cantillon, Daire M., Baxendale, Sarah, de la Vega de León, Antonio, Mahieu, Virginia N., Osgood, Richard T., Wilson, Charlotte Donald, Bull, James C., Waddell, Simon J., Whitfield, Tanya T., Ward, Simon E., Kros, Corné J., Richardson, Guy P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8133782/
https://ncbi.nlm.nih.gov/pubmed/33735112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.145704
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