ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity

Aminoglycoside (AG) antibiotics are widely used to prevent life-threatening infections, and cisplatin is used in the treatment of various cancers, but both are ototoxic and result in loss of sensory hair cells from the inner ear. ORC-13661 is a new drug that was derived from PROTO-1, a compound firs...

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發表在:JCI Insight
Main Authors: Kitcher, Siân R., Kirkwood, Nerissa K., Camci, Esra D., Wu, Patricia, Gibson, Robin M., Redila, Van A., Simon, Julian A., Rubel, Edwin W., Raible, David W., Richardson, Guy P., Kros, Corné J.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2019
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693895/
https://ncbi.nlm.nih.gov/pubmed/31391343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126764
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