ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity

Aminoglycoside (AG) antibiotics are widely used to prevent life-threatening infections, and cisplatin is used in the treatment of various cancers, but both are ototoxic and result in loss of sensory hair cells from the inner ear. ORC-13661 is a new drug that was derived from PROTO-1, a compound firs...

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Publicat a:JCI Insight
Autors principals: Kitcher, Siân R., Kirkwood, Nerissa K., Camci, Esra D., Wu, Patricia, Gibson, Robin M., Redila, Van A., Simon, Julian A., Rubel, Edwin W., Raible, David W., Richardson, Guy P., Kros, Corné J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693895/
https://ncbi.nlm.nih.gov/pubmed/31391343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126764
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