Discovery of 3-Alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as Selective, Orally Bioavailable CHK1 Inhibitors

[Image: see text] Inhibitors of checkpoint kinase 1 (CHK1) are of current interest as potential antitumor agents, but the most advanced inhibitor series reported to date are not orally bioavailable. A novel series of potent and orally bioavailable 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbon...

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Main Authors: Lainchbury, Michael, Matthews, Thomas P., McHardy, Tatiana, Boxall, Kathy J., Walton, Michael I., Eve, Paul D., Hayes, Angela, Valenti, Melanie R., de Haven Brandon, Alexis K., Box, Gary, Aherne, G. Wynne, Reader, John C., Raynaud, Florence I., Eccles, Suzanne A., Garrett, Michelle D., Collins, Ian
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2012
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3506129/
https://ncbi.nlm.nih.gov/pubmed/23082860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3012933
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