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Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange
The protein kinase Chk2 (checkpoint kinase 2) is a major effector of the replication checkpoint. Chk2 activation is initiated by phosphorylation of Thr68, in the serine–glutamine/threonine–glutamine cluster domain (SCD), by ATM. The phosphorylated SCD-segment binds to the FHA domain of a second Chk2...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1500991/ https://ncbi.nlm.nih.gov/pubmed/16794575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601209 |
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