AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth

Por Grimshaw, Kyla M, Hunter, Lisa-Jane K, Yap, Timothy A, Heaton, Simon, Walton, Mike I, Woodhead, Steve, Fazal, Lynsey, Reule, Matthias, Davies, Thomas G., Seavers, Lisa C., Lock, Victoria, Lyons, John F., Thompson, Neil T., Workman, Paul, Garrett, Michelle D.
Publicado no Mol Cancer Ther (2010)

Preclinical pharmacology, antitumor activity and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930

Por Yap, Timothy A., Walton, Mike I., Hunter, Lisa-Jane K., Valenti, Melanie, de Haven Brandon, Alexis, Eve, Paul D., Ruddle, Ruth, Heaton, Simon P., Henley, Alan, Pickard, Lisa, Vijayaraghavan, Gowri, Caldwell, John J., Thompson, Neil T., Aherne, Wynne, Raynaud, Florence I., Eccles, Suzanne A., Workman, Paul, Collins, Ian, Garrett, Michelle D.
Publicado no Mol Cancer Ther (2010)

CCT244747 is a novel, potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs

Por Walton, Mike I, Eve, Paul D, Hayes, Angela, Valenti, Melanie R, De Haven Brandon, Alexis K, Box, Gary, Hallsworth, Albert, Smith, Elizabeth L, Boxall, Kathy J, Lainchbury, Michael, Matthews, Thomas P, Jamin, Yann, Robinson, Simon P, Aherne, G Wynne, Reader, John C, Chesler, Louis, Raynaud, Florence I, Eccles, Suzanne A, Collins, Ian, Garrett, Michelle D
Publicado em 2012

The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eμ-MYC driven B-cell lymphoma

Por Walton, Mike I., Eve, Paul D., Hayes, Angela, Henley, Alan T., Valenti, Melanie R., De Haven Brandon, Alexis K., Box, Gary, Boxall, Kathy J., Tall, Matthew, Swales, Karen, Matthews, Thomas P., McHardy, Tatiana, Lainchbury, Michael, Osborne, James, Hunter, Jill E., Perkins, Neil D., Aherne, G. Wynne, Reader, John C., Raynaud, Florence I., Eccles, Suzanne A., Collins, Ian, Garrett, Michelle D.
Publicado no Oncotarget (2015)