Chemical approaches to targeted protein degradation through modulation of the ubiquitin–proteasome pathway

Por Collins, Ian, Wang, Hannah, Caldwell, John J., Chopra, Raj
Publicado no Biochem J (2017)

Synthesis of a Ribose‐Incorporating Medium Ring Scaffold via a Challenging Ring‐Closing Metathesis Reaction

Por Rankin, Stuart S., Caldwell, John J., Cronin, Nora B., van Montfort, Rob L. M., Collins, Ian
Publicado no European J Org Chem (2016)

Molecular mechanisms of human IRE1 activation through dimerization and ligand binding

Por Joshi, Amar, Newbatt, Yvette, McAndrew, P. Craig, Stubbs, Mark, Burke, Rosemary, Richards, Mark W., Bhatia, Chitra, Caldwell, John J., McHardy, Tatiana, Collins, Ian, Bayliss, Richard
Publicado no Oncotarget (2015)

CCT241533 is a potent and selective inhibitor of CHK2 which potentiates the cytotoxicity of PARP inhibitors

Por Anderson, Victoria E, Walton, Michael I, Eve, Paul D, Boxall, Katherine J, Antoni, Laurent, Caldwell, John J, Pearl, Laurence H, Oliver, Antony W, Collins, Ian, Garrett, Michelle D
Publicado no Cancer Res (2011)

Synthesis and Evaluation of a 2,11‐Cembranoid‐Inspired Library

Por Welford, Amanda J, Caldwell, John J., Liu, Manjuan, Richards, Meirion, Brown, Nathan, Lomas, Cara, Tizzard, Graham J., Pitak, Mateusz B., Coles, Simon J., Eccles, Suzanne A., Raynaud, Florence I., Collins, Ian
Publicado no Chemistry (2016)

Discovery of 4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)

Por McHardy, Tatiana, Caldwell, John J., Cheung, Kwai-Ming, Hunter, Lisa J., Taylor, Kevin, Rowlands, Martin, Ruddle, Ruth, Henley, Alan, de Haven Brandon, Alexis, Valenti, Melanie, Davies, Thomas G., Fazal, Lynsey, Seavers, Lisa, Raynaud, Florence I., Eccles, Suzanne A., Aherne, G. Wynne, Garrett, Michelle D., Collins, Ian
Publicado em 2010

Preclinical pharmacology, antitumor activity and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930

Por Yap, Timothy A., Walton, Mike I., Hunter, Lisa-Jane K., Valenti, Melanie, de Haven Brandon, Alexis, Eve, Paul D., Ruddle, Ruth, Heaton, Simon P., Henley, Alan, Pickard, Lisa, Vijayaraghavan, Gowri, Caldwell, John J., Thompson, Neil T., Aherne, Wynne, Raynaud, Florence I., Eccles, Suzanne A., Workman, Paul, Collins, Ian, Garrett, Michelle D.
Publicado no Mol Cancer Ther (2010)