Molecular mechanisms of human IRE1 activation through dimerization and ligand binding

IRE1 transduces the unfolded protein response by splicing XBP1 through its C-terminal cytoplasmic kinase-RNase region. IRE1 autophosphorylation is coupled to RNase activity through formation of a back-to-back dimer, although the conservation of the underlying molecular mechanism is not clear from ex...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Joshi, Amar, Newbatt, Yvette, McAndrew, P. Craig, Stubbs, Mark, Burke, Rosemary, Richards, Mark W., Bhatia, Chitra, Caldwell, John J., McHardy, Tatiana, Collins, Ian, Bayliss, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4536996/
https://ncbi.nlm.nih.gov/pubmed/25968568
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