Epidermal Growth Factor Receptor Dimerization and Activation Require Ligand-Induced Conformational Changes in the Dimer Interface

Structural studies have shown that ligand-induced epidermal growth factor receptor (EGFR) dimerization involves major domain rearrangements that expose a critical dimerization arm. However, simply exposing this arm is not sufficient for receptor dimerization, suggesting that additional ligand-induce...

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Detalhes bibliográficos
Main Authors: Dawson, Jessica P., Berger, Mitchell B., Lin, Chun-Chi, Schlessinger, Joseph, Lemmon, Mark A., Ferguson, Kathryn M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190273/
https://ncbi.nlm.nih.gov/pubmed/16107719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.17.7734-7742.2005
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