A structure-based model for ligand binding and dimerization of EGF receptors

On the basis of the 3D structures of the extracellular ligand-binding domains of the epidermal growth factor (EGF) receptor (EGFR) and ErbB3, a mechanism has been proposed for how the extracellular region of the EGFR is maintained in an autoinhibited configuration and for how EGF binding induces EGF...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Klein, Peter, Mattoon, Dawn, Lemmon, Mark A., Schlessinger, Joseph
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2004
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327119/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14732694/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307285101
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