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A structure-based model for ligand binding and dimerization of EGF receptors

On the basis of the 3D structures of the extracellular ligand-binding domains of the epidermal growth factor (EGF) receptor (EGFR) and ErbB3, a mechanism has been proposed for how the extracellular region of the EGFR is maintained in an autoinhibited configuration and for how EGF binding induces EGF...

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Autors principals: Klein, Peter, Mattoon, Dawn, Lemmon, Mark A., Schlessinger, Joseph
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC327119/
https://ncbi.nlm.nih.gov/pubmed/14732694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307285101
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