A structure-based model for ligand binding and dimerization of EGF receptors
On the basis of the 3D structures of the extracellular ligand-binding domains of the epidermal growth factor (EGF) receptor (EGFR) and ErbB3, a mechanism has been proposed for how the extracellular region of the EGFR is maintained in an autoinhibited configuration and for how EGF binding induces EGF...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2004
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327119/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14732694/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307285101 |
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