Synthesis of a Ribose‐Incorporating Medium Ring Scaffold via a Challenging Ring‐Closing Metathesis Reaction

A practical synthesis of a novel oxabicyclo[6.2.1]undecenetriol useful as a medicinal chemistry scaffold has been developed starting from l‐ribose. The sequence involves an oxidation/Grignard addition sequence and a challenging ring‐closing metathesis (RCM) reaction as the ring forming step. Explora...

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Detalhes bibliográficos
Publicado no:European J Org Chem
Main Authors: Rankin, Stuart S., Caldwell, John J., Cronin, Nora B., van Montfort, Rob L. M., Collins, Ian
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5157775/
https://ncbi.nlm.nih.gov/pubmed/28042283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ejoc.201600756
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