Discovery of 4-Amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides As Selective, Orally Active Inhibitors of Protein Kinase B (Akt)

[Image: see text] Protein kinase B (PKB or Akt) is an important component of intracellular signaling pathways regulating growth and survival. Signaling through PKB is frequently deregulated in cancer, and inhibitors of PKB therefore have potential as antitumor agents. The optimization of lipophilic...

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Bibliografiske detaljer
Main Authors: McHardy, Tatiana, Caldwell, John J., Cheung, Kwai-Ming, Hunter, Lisa J., Taylor, Kevin, Rowlands, Martin, Ruddle, Ruth, Henley, Alan, de Haven Brandon, Alexis, Valenti, Melanie, Davies, Thomas G., Fazal, Lynsey, Seavers, Lisa, Raynaud, Florence I., Eccles, Suzanne A., Aherne, G. Wynne, Garrett, Michelle D., Collins, Ian
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2010
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832868/
https://ncbi.nlm.nih.gov/pubmed/20151677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901788j
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