Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus

New, more-effective drugs for the treatment of lung disease caused by nontuberculous mycobacteria (NTM) are needed. Among NTM opportunistic pathogens, Mycobacterium abscessus is the most difficult to cure and intrinsically multidrug resistant. In a whole-cell screen of a compound collection active a...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Negatu, Dereje Abate, Beuchel, Andreas, Madani, Abdeldjalil, Alvarez, Nadine, Chen, Chao, Aragaw, Wassihun Wedajo, Zimmerman, Matthew D., Laleu, Benoît, Gengenbacher, Martin, Dartois, Véronique, Imming, Peter, Dick, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2021
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Mechanisms of Action: Physiological Effects
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284461/
https://ncbi.nlm.nih.gov/pubmed/34001512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00676-21
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