ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma

Diffuse intrinsic pontine glioma (DIPG) is a lethal childhood brainstem tumour, with a quarter of patients harbouring somatic mutations in ACVR1, encoding the serine/threonine kinase ALK2. Despite being an amenable drug target, little has been done to-date to systematically evaluate the role of ACVR...

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Bibliographic Details
Published in:Commun Biol
Main Authors: Carvalho, Diana, Taylor, Kathryn R., Olaciregui, Nagore Gene, Molinari, Valeria, Clarke, Matthew, Mackay, Alan, Ruddle, Ruth, Henley, Alan, Valenti, Melanie, Hayes, Angela, Brandon, Alexis De Haven, Eccles, Suzanne A., Raynaud, Florence, Boudhar, Aicha, Monje, Michelle, Popov, Sergey, Moore, Andrew S., Mora, Jaume, Cruz, Ofelia, Vinci, Mara, Brennan, Paul E., Bullock, Alex N., Carcaboso, Angel Montero, Jones, Chris
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509210/
https://ncbi.nlm.nih.gov/pubmed/31098401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0420-8
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