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DIPG-29. PRECLINICAL EFFICACY OF COMBINED ACVR1 AND PI3K/mTOR INHIBITION IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

Somatic mutations in ACVR1, encoding the serine/threonine kinase ALK2 receptor, are found in a quarter of DIPG patients. Treatment of ACVR1-mutant DIPG patient-derived models with multiple ALK2 inhibitor chemotypes leads to a reduction in cell viability in vitro and extended survival in orthotopic x...

詳細記述

保存先:
書誌詳細
出版年:Neuro Oncol
主要な著者: Carvalho, Diana, Olaciregui, Nagore Gene, Ruddle, Ruth, Donovan, Adam, Pal, Akos, Raynaud, Florence, Richardson, Peter J, Carcaboso, Angel Montero, Jones, Chris
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012753/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.122
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