DIPG-29. PRECLINICAL EFFICACY OF COMBINED ACVR1 AND PI3K/mTOR INHIBITION IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

Somatic mutations in ACVR1, encoding the serine/threonine kinase ALK2 receptor, are found in a quarter of DIPG patients. Treatment of ACVR1-mutant DIPG patient-derived models with multiple ALK2 inhibitor chemotypes leads to a reduction in cell viability in vitro and extended survival in orthotopic x...

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Pubblicato in:Neuro Oncol
Autori principali: Carvalho, Diana, Olaciregui, Nagore Gene, Ruddle, Ruth, Donovan, Adam, Pal, Akos, Raynaud, Florence, Richardson, Peter J, Carcaboso, Angel Montero, Jones, Chris
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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Abstracts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012753/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.122
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