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DIPG-29. PRECLINICAL EFFICACY OF COMBINED ACVR1 AND PI3K/mTOR INHIBITION IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)
Somatic mutations in ACVR1, encoding the serine/threonine kinase ALK2 receptor, are found in a quarter of DIPG patients. Treatment of ACVR1-mutant DIPG patient-derived models with multiple ALK2 inhibitor chemotypes leads to a reduction in cell viability in vitro and extended survival in orthotopic x...
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| 出版年: | Neuro Oncol |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6012753/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.122 |
| タグ: |
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