Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1-Mutant Diffuse Intrinsic Pontine Glioma

Somatic mutations in ACVR1 are found in a quarter of children with diffuse intrinsic pontine glioma (DIPG), but there are no ACVR1 inhibitors licensed for the disease. Using an artificial intelligence–based platform to search for approved compounds for ACVR1-mutant DIPG, the combination of vandetani...

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Bibliografski detalji
Izdano u:Cancer Discov
Glavni autori: Carvalho, Diana M., Richardson, Peter J., Olaciregui, Nagore, Stankunaite, Reda, Lavarino, Cinzia, Molinari, Valeria, Corley, Elizabeth A., Smith, Daniel P., Ruddle, Ruth, Donovan, Adam, Pal, Akos, Raynaud, Florence I., Temelso, Sara, Mackay, Alan, Overington, John P., Phelan, Anne, Sheppard, David, Mackinnon, Andrew, Zebian, Bassel, Al-Sarraj, Safa, Merve, Ashirwad, Pryce, Jeremy, Grill, Jacques, Hubank, Michael, Cruz, Ofelia, Morales La Madrid, Andres, Mueller, Sabine, Carcaboso, Angel M., Carceller, Fernando, Jones, Chris
Format: Artigo
Jezik:Inglês
Izdano: American Association for Cancer Research 2022
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612365/
https://ncbi.nlm.nih.gov/pubmed/34551970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-1201
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